In Sept 2006 Charles took up the position of Clinical Senior Lecturer in Colorectal Surgery at Barts and the London and the Homerton University NHS Foundation Trusts. During this time he has developed 3 main research programmes in which he leads and supports a mixed group of clinicians and scientists at different career stages.
He has developed a national and international profile in his areas of interest (mainly neurogastroenterology and benign coloproctology) with over 10 grant awards as Principle Investigator, 50 peer-reviewed original research articles, 20 published reviews and 40 invited national and international lectures. In April 2011 he moved his clinical commitment entirely to Barts and the London NHS Trust where he further aligned his clinical practice in chronic bowel disorders (especially constipation and faecal incontinence) with translational research objectives within the Academic Surgical, Colorectal development and GI physiology Units (Centre for Digestive Diseases, Blizard Institute Of Cell and Molecular Science). He is a Co-Director of the National Centre for Bowel Research and Surgical Innovation and is adminstrative Chair of the Bowel & Cancer Research Grants Committee.